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KMID : 0387820150220020190
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Clinical Pediatric Hematology-Oncology
2015 Volume.22 No. 2 p.190 ~ p.194
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Kim Beom-Joon
Kim Seong-Koo
Han Seung-Beom
Lee Jae-Wook
Yoon Jong-Seo
Chung Nack-Gyun
Cho Bin
Kang Jin-Han
Kim Hack-Ki
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Abstract
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Respiratory viral infection has been reported as a risk factor for invasive pulmonary aspergillosis (IPA) in hematopoietic cell transplantation (HCT) recipients, and IPA following influenza has been reported. We report a 13-year-old boy diagnosed with IPA following influenza. He received allogeneic HCT and then received glucocorticoids for chronic graft-versus-host disease. On admission, he complained of non-neutropenic fever and dyspnea. He was diagnosed with influenza A via a polymerase chain reaction (PCR) test from nasopharyngeal swab, and oseltamivir was administered. Fever re-emerged nine days later and repeat PCR was positive for influenza A. His fever did not resolve despite triple antiviral and empirical antibiotic therapy. On hospital day 22, IPA was diagnosed based on chest computed tomography and positive serum galactomannan results, and his symptoms improved with voriconazole therapy. However, he died of uncontrolled bronchiolitis obliterans on hospital day 128. IPA should be considered a complication of influenza in immunocompromised children.
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KEYWORD
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Influenza, Invasive pulmonary aspergillosis, Hematopoietic stem cell transplantation, Acute myeloid leukemia, Child
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